THE KNOWLEDGE NEXUS
“Discovery consists of seeing what everybody has seen and thinking what nobody has thought.”
— Albert Szent-Györgyi
Topic 1: Long-Acting Drug Delivery Implants
Our lab focuses on the development of both biodegradable and non-degradable long-acting implants designed for sustained drug release. This includes:
- Materials science: Selection and optimization of polymers and excipients.
- Process design: Engineering scalable and reproducible manufacturing methods.
- Physicochemical characterization: In-depth analysis of implant structure, drug-polymer interactions, and degradation behavior.
- Drug release modeling: Mechanistic and data-driven approaches to predict in-vitro and in-vivo drug release kinetics.
Topic 2: Innovative Formulations for Unmet Medical Needs
We explore novel compositions and manufacturing processes to create long-acting delivery systems that address critical gaps in current therapies. These systems are tailored to improve patient compliance, reduce dosing frequency, and enhance therapeutic outcomes.
Topic 3: Continuous Manufacturing Using Twin-Screw Extrusion
Our lab leverages twin-screw extrusion (TSE) technology to enable continuous production of advanced drug delivery systems. Key applications include:
- Granules for solid oral dosage forms: Optimized for flowability, compressibility, and controlled release.
- Amorphous solid dispersions: Designed to enhance the solubility and bioavailability of poorly water-soluble drugs.
- Powder blends for dry powder inhalation: Engineered for aerodynamic performance and pulmonary delivery efficiency.